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KMID : 0363319970180010147
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Journal of Korean Oriental Internal Medicine
1997 Volume.18 No. 1 p.147 ~ p.155
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Effect of Salviae-radix on oxidant-induced impairment of membrane transport function in renal tubules
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Kim Sang-Beum
Jung Ji-Chun
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Abstract
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This study was undertaken to determine whether Salviae-radix (SVR) exraction exerts benefical effect against oxidant-induced inhibition of tetraethylammonium (TEA) uptake which is actively secreted by renal proximal tubules. TEA uptake increased as function of incubation time to 60 min. When renal cortical slices were exposed to 50 mM H₂O₂, TEA uptake was significantly inhibited. The inhibition was significantly protected by addition of 0.5% SVR extraction. The benefical effect of SVR was dose-dependent over the concentration range of 0.1-1%; H₂O₂ (50 mM)-induced inhibition of TEA uptake was completely protected by 0.5-1% SVR extraction. H₂O₂ increased LDH release which was accompanied by an increase in lipid peroxidation in renal cortical slices. These changes were prevented by 0.5% SVR. These results suggest that SVR exerts benefical effect against oxidant-induced impairment of membrane transport function, this effect may be due to by an antioxidant action.
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KEYWORD
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salviae radix, H₂O₂ , renal cortical slices, TEA uptake, membrane transport function
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